Cannabis, the Constitution and States Rights

The change in the legal status of the cannabis plant has been a mixed blessing. The industry is now entering the arena of dynamic market capitalism despite many of its pioneers still serving lengthy prison sentences and many seriously ill patients still going without.   Too often these new corporate growers don’t have the same passion and spiritual attachment to the plant that the former outlaws who grew it did. This has many implications for both business and government. We need to avoid the negative baggage of entrepreneurship with its crony capitalism, cut-throat competition, and l...
More

Dispensaries v. Pharmacies: Why Are They Regulated So Differently?

In several court decisions, the California Supreme Court has determined that a doctor’s recommendation for the medical use of cannabis is, for all intents and purposes, the equivalent of a prescription. Since that is the case, that determination should have application to dispensaries. Photo: Cannabis Museum, Ohio Historically from the 1850s until 1942, cannabis-containing prescriptions and patent medicines were available in pharmacies. One needs to ask why dispensaries and pharmacies are not treated under the same regulations today. Dispensaries ought to have a legal obligation to ...
More

Painless: The Case of Too Much Anandamide

When it comes to pain it looks like you can’t have too much Anandamide. Anandamide, aka “the bliss molecule”, or N-arachidonoylethanolamine (AEA) is an endogenous cannabinoid produced by the human body that binds to the endocannabinoid system similar to plant-derived THC. Anandamide, the "Bliss Molecule" Recently an article appeared in the British Journal of Anesthesia that discussed an unusual case of a woman who felt little or no pain. When the case came to the attention of researchers, what they found provides us with more insight regarding the analgesic and anxiolytic effects not o...
More

Report: New Cannabinoid Drug Interactions

Picture taken on January 15, 2012 in Lille, northern France, of drug capsules. AFP PHOTO PHILIPPE HUGUEN (Photo credit should read PHILIPPE HUGUEN/AFP/Getty Images) Adrian Devitt-Lee of Project CBD writes: "The interactions between plant cannabinoids and a drug-metabolizing enzyme called carboxylesterase 1 (CES1) was recently published in Drug Metabolism and Distribution. Researchers at the Universities of Michigan and Florida showed that THC, CBD, and cannabinol (CBN) all inhibit CES1. CES1 is important for activating or inactivating drugs that regulate blood pressure, as well as the ...
More

Commentary: This is Your “Little Brain” on Cannabis

This article from Psychology Today brings up an important topic of conversation for medical professionals. Perhaps the high concentration of CB1 receptors in the cerebellum is a protective adaptation. Poor coordination and difficulty with visual tracking should be a warning to slow down, both in terms of cannabinoid ingestion and movement. Unfortunately, poor judgement on the part of the frontal cortex and reward circuitry is able to override this primitive early warning system and we all know the outcome when that happens. Continuing to ignore the brain’s innate warning circuitry would b...
More

Study: Cannabis in Oncology Practice

Image: Royal Queen Seeds Promoting MMJ Among Oncologist in the USA By John Taenzler, Ph.D. for Cannabis Business Executive In October 2018, a survey was conducted among 87 oncologists (ONCs) in 19 of the States where medical marijuana (MMJ) has been approved and available.  An objective of this research was to assess the depth of knowledge about cannabis pharmacology, state-specific regulations, and attitudes of national medical organizations toward MMJ. In examining and assessing the perceptions and attitudes of these ONCs towards MMJ, physicians were asked about their curre...
More

A Brief History of Medical Cannabis and Cannabinoids in the U.S.

The Ayurvedic Medicine Materia Medica Since the late 1940s and early 1950s, both state and federal entities have assiduously avoided treating cannabis as the medicine it has been for over 4,000 years. Cannabis has been recognized as a medicine since at least 2637 B.C.E. when it was included in the first known pharmacopoeia, the Ping Ts’ao Ching, alleged to be written by the second Emperor of China, Shen Neng. Cannabis has appeared in all subsequent major pharmacopoeias including an Ayurvedic Medicine Materia Medica, dated from between 1100 B.C.E. and 1700 B.C.E., as well as the Ebers Papy...
More

Older Adults Tolerate Medical Marijuana Well

From: Grandmas Smoking Weed The following article is an excellent example of the value of community-based and patient-centered observational study in developing a better understanding of the therapeutic usefulness of cannabinoid-based medicine for specific conditions, in this case chronic pain and opioid analgesic dependence. The fact that it was carried out through chart review in a clinic seeing mostly older adults is all the more encouraging, as the efficacy and tolerability of THC-containing cannabis medicines among the elderly might be expected to be lower than among younger populatio...
More

Study: Review of CBD for treatment-resistant epilepsy

This recent clinical trial concerning cannabidiol (CBD) and seizure disorders demonstrated that “CBD might reduce seizure frequency and an adequate safety profile in children and young adults with highly treatment-resistant epilepsy.” In 2016, doctors across the United States began an open-label interventional trial focused on patients (aged 1–30 years) with severe, intractable, childhood-onset, treatment-resistant epilepsy. These patients were all receiving stable doses of anti-epileptic medications prior to study entry and were enrolled in an expanded-access program at 11 epilepsy cente...
More

Commentary: Could cannabis be key to combat the opioid crisis?

This is an interesting review based on U.S. experience, but proposing the use of cannabis to treat pain and opiate misuse in Australia, which has the second-highest rate of opioid analgesic use in the world. This highlights the important of reviews by highlighting the potential for good in cotnrast to the counter attack highlighting potential negative consequences. Not bad for a commercial online publication, I say.-Dr. David Ostrow Could cannabis be key to combat the opioid crisis? by Zoe Gross for FinFeed Weed’s legal forays began in the medical space as a way to treat chronic...
More